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KMID : 0387420210320010025
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Korean Society of Oriental Neuropsychiatry
2021 Volume.32 No. 1 p.25 ~ p.37
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Effects of JSB, a Korean Medicine, on Behaviors and Biological Factors in a Mouse Model of Depression Induced by Restraint Stress
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Shin Youn-Min
Lim Hyung-Taeck
Hwang Eun-Young
Kim Ka-Na
Lee Won-Kil
Kim Yeon-Gyeong
Jang Hee-Jin
Choi Jeong-June
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Abstract
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Objectives: Depression is a mood disorder showing low energy, loss of interest, anhedonia, and anxiety.
It affects a patients' daily life. This disease is considered a social problem because the patient may commit suicide in extreme cases. JSB is composed of 12 Korean medicinal herbs. It has been prescribed to patients with depression. The objective of this study is to investigate anti-depressive effects of JSB on restraint stress-induced depression in a mouse model.
Methods: Depression was induced by restraint stress. Mice were orally administered JSB at 10, 20, or 40 mg/kg for 14 days. Forced swimming test (FST) and open field test (OFT) were performed. Brain-derived neurotrophic factor (BDNF) mRNA level was measured by real time-PCR. Plasma levels of corticosterone and serotonin were measured by ELISA. Blood levels of AST and ALS were measured using a biochemical analyzer.
Results: JSB treatment significantly reduced the immobility time in FST. BDNF mRNA level was increased by JSB treatment in the hippocampi of mice. Although the expression of TNF-α was also increased by JSB, such increase was not statistically significant. The increase of corticosterone level in plasma induced by restraint stress was significantly down-regulated by JSB. JSB reduced blood level of AST, but not ALT.
Conclusions: JSB has a potential to manage depression, setting a foundation for clinical application of Korean medicine with safety.
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KEYWORD
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Herbal medicine, Depression, Restraint stress, Brain-derived neurotrophic factor
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